Hirano bodies and other cytoskeletal abnormalities develop in fetal rat CNS grafts isolated for long periods in peripheral nerve
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Auteurs : Laurie C. Doering [Canada] ; Albert J. Aguayo [Canada]Source :
- Brain Research [ 0006-8993 ] ; 1987.
English descriptors
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Abstract
Abstract: Dissociated cells from the telencephalic region of 12-day-old rat embryos were cultured in vitro for 3–5 days and transplanted into segments of the sciatic nerve of adult inbred rats. Transplanted progenitor cells survived, differentiated, and expressed various morphological and molecular features characteristics of neurons and glia. Six to twelve months after grafting, many neurons underwent changes compatible with an alteration of their cytoskeleton. These included; (1) a strong perikaryal immunoreactivity to the monoclonal antibody RT97, directed against the 200-kDa phosphorylated neurofilament subunit and (2) the formation of Hirano bodies within dendrites. Similar cytoskeletal abnormalities are seen as part of the spectrum of changes that occur in some human neurodegenerative diseases and in aging. The approach we have used may provide new possibilities for the study of the pathogenesis of these lesions under controlled laboratory conditions.
Url:
DOI: 10.1016/0006-8993(87)91180-2
Affiliations:
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Doering</name><affiliation wicri:level="3"><country xml:lang="fr">Canada</country><wicri:regionArea>The Neuroscience Unit, Montreal General Hospital and McGill University, Montreal</wicri:regionArea><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Aguayo, Albert J" sort="Aguayo, Albert J" uniqKey="Aguayo A" first="Albert J." last="Aguayo">Albert J. Aguayo</name><affiliation wicri:level="3"><country xml:lang="fr">Canada</country><wicri:regionArea>The Neuroscience Unit, Montreal General Hospital and McGill University, Montreal</wicri:regionArea><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Brain Research</title><title level="j" type="abbrev">BRES</title><idno type="ISSN">0006-8993</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1987">1987</date><biblScope unit="volume">401</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="178">178</biblScope><biblScope unit="page" to="184">184</biblScope></imprint><idno type="ISSN">0006-8993</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0006-8993</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>200-kDA Neurofilament</term><term>Cytoskeletal abnormality</term><term>Hirano body</term><term>Long-term CNS transplant</term><term>Peripheral nerve</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Dissociated cells from the telencephalic region of 12-day-old rat embryos were cultured in vitro for 3–5 days and transplanted into segments of the sciatic nerve of adult inbred rats. Transplanted progenitor cells survived, differentiated, and expressed various morphological and molecular features characteristics of neurons and glia. Six to twelve months after grafting, many neurons underwent changes compatible with an alteration of their cytoskeleton. These included; (1) a strong perikaryal immunoreactivity to the monoclonal antibody RT97, directed against the 200-kDa phosphorylated neurofilament subunit and (2) the formation of Hirano bodies within dendrites. Similar cytoskeletal abnormalities are seen as part of the spectrum of changes that occur in some human neurodegenerative diseases and in aging. The approach we have used may provide new possibilities for the study of the pathogenesis of these lesions under controlled laboratory conditions.</div></front></TEI><affiliations><list><country><li>Canada</li></country><region><li>Québec</li></region><settlement><li>Montréal</li></settlement></list><tree><country name="Canada"><region name="Québec"><name sortKey="Doering, Laurie C" sort="Doering, Laurie C" uniqKey="Doering L" first="Laurie C." last="Doering">Laurie C. Doering</name></region><name sortKey="Aguayo, Albert J" sort="Aguayo, Albert J" uniqKey="Aguayo A" first="Albert J." last="Aguayo">Albert J. Aguayo</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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